Hypermetabolism, Hyperphagia, and Reduced Adiposity in Tankyrase-Deficient Mice
نویسندگان
چکیده
منابع مشابه
Hypermetabolism, Hyperphagia, and Reduced Adiposity in Tankyrase-Deficient Mice
OBJECTIVE Tankyrase (TNKS) is a Golgi-associated poly-ADP-ribose polymerase that is implicated in the regulation of GLUT4 trafficking in 3T3-L1 adipocytes. Its chromosomal locus 8p23.1 is linked to monogenic forms of diabetes in certain kindred. We hypothesize that TNKS is involved in energy homeostasis in mammals. RESEARCH DESIGN AND METHODS Gene-trap techniques were used to ablate TNKS expr...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2009
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db08-1781